Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

The accumulation of irreparable cellular damage restricts healthspan after acute stress or
natural aging. Senescent cells are thought to impair tissue function, and their genetic …

Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …

Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known
epitranscriptional regulatory mechanism affecting central biological processes, but its …

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

INTRODUCTION During aging, most organs in mammals become smaller (miniaturize) or
thinner, and their functions and regenerative capability also decline. Histologically, tissue …

This review gives an account of how the cell repairs DNA damage and presents evidence
that DNA damage contributes to aging and cancer, with the outcome dependent on the type …