Congenital myasthenic syndromes (CMS) are a heterogeneous group of disorders
characterized by impaired neuromuscular signal transmission due to germline pathogenic …

The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron
nerve terminal and its muscle fiber that are responsible for converting electrical impulses …

Nicotinic acetylcholine receptors (nAChRs) comprise a family of pentameric ligand-gated ion
channels widely distributed in the central and peripheric nervous system and in non …

Muscle Specific Kinase myasthenia gravis (MuSK-MG) is an autoimmune disease that
impairs neuromuscular transmission leading to generalized muscle weakness. Compared to …

The excitability of interneurons requires Nav1. 1, the α subunit of the voltage-gated sodium
channel. Nav1. 1 deficiency and mutations reduce interneuron excitability, a major …

Post-synaptic specialization is critical to the neurotransmitter release and action potential
conduction. The neuromuscular junctions (NMJs) are the synapses between the motor …

Synapse formation is a very elaborate process dependent upon accurate coordination of pre
and post-synaptic specialization, requiring multiple steps and a variety of receptors and …

The acetylcholine receptor (AChR) is highly concentrated at the neuromuscular junction
(NMJ), ensuring efficient signal transmission from motoneurons to muscle fibers. This …

Muscle-specific kinase (MuSK) is the key regulator of neuromuscular junction development.
MuSK acts via several distinct pathways and is responsible for pre-and postsynaptic …

Background Early detection is essential to improve the survival and life quality of lung
cancer (LC) patients. Changes of peripheral blood DNA methylation could be associated …