Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

Although intratumoral genomic heterogeneity can impede cancer research and treatment,
less is known about the effects of phenotypic heterogeneities. To investigate the role of cell …

Tumors are composed of heterogeneous phenotypes, each having different sensitivities to
the microenvironment. One microenvironment characteristic–matrix stiffness–helps to …

Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …

The mechanical properties of the cell nucleus are increasingly recognized as critical in many
biological processes. The deformability of the nucleus determines the ability of immune and …

Tumors are heterogeneous and composed of cells with different dissemination abilities.
Despite significant effort, there is no universal biological marker that serves as a metric for …

During metastasis, all cancer types must migrate through crowded multicellular
environments. Simultaneously, cancers appear to change their biophysical properties …

Bioelectricity is the electrical activity that occurs within living cells and tissues. This activity is
critical for regulating homeostatic cellular function and communication, and disruptions of …

The use of biomaterials has substantially contributed to both our understanding of
tumorigenesis and our ability to identify and capture tumour cells in vitro and in vivo. Natural …