The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Sex-determining region Y-box2 (SOX2), a master regulator of embryonic and induced
pluripotent stem cells, drives cancer stem cells (CSCs) properties, fuels tumor initiation, and …

Long noncoding RNAs (lncRNAs) or exosomes have recently been shown to play vital
regulatory or communication roles in cancer biology. However, the roles and mechanisms of …

SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …

The pluripotency-associated transcription factor SOX2 is essential during mammalian
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …

Over the past 5 years, the advent of combination therapeutic strategies has substantially
reshaped the clinical management of patients with advanced prostate cancer. However …

An important clinical challenge in prostate cancer therapy is the inevitable transition from
androgen-sensitive to castration-resistant and metastatic prostate cancer. Albeit the …

Background High levels of SOX2 protein are correlated with increased dissemination of
breast cancer. However, the underlying molecular mechanisms are not fully understood …