Cells in tissues and organs are continuously subjected to oxidative stress and free radicals
on a daily basis. This free radical attack has exogenous or endogenous (intracellular) origin …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …

Background: The body of evidence available from published literature during the past three
decades indicates that reactive oxygen species and reactive nitrogen species can induce …

The comet assay is widely used in human biomonitoring to measure DNA damage as a
marker of exposure to genotoxic agents or to investigate genoprotective effects. Studies …

Oxidative DNA damage plays crucial roles in the pathogenesis of numerous diseases
including cancer. 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the most representative …

8-Oxoguanine DNA glycosylase is essential for maintaining genomic integrity and stability,
while its abnormal activity may lead to the disturbance in the normal DNA damage repair …

Redox imbalance is resulted from the destruction of balance between oxidants and
antioxidants. The dominant oxidants are reactive oxygen species (ROS), which are involved …

Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and
extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not …

The NEIL3 DNA repair gene is induced in cells or animal models experiencing oxidative or
inflammatory stress along with oxidation of guanine (G) to 8-oxo-7, 8-dihydroguanine (OG) …