Diversity of Molecular Functions of RNA-Binding Ubiquitin Ligases from the MKRN Protein Family

EA Guseva, MA Emelianova, VN Sidorova… - Biochemistry …, 2024 - Springer
Makorin RING finger protein family includes four members (MKRN1, MKRN2, MKRN3, and
MKRN4) that belong to E3 ubiquitin ligases and play a key role in various biological …

Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation

AJ Middleton, FM Barzak, TJ Fokkens, K Nguyen… - Structure, 2023 - cell.com
Inflammation is essential for healthy immune function, wound healing, and resolution of
infection. RIG-I is a key RNA sensor that initiates an immune response, with activation and …

LIN28B induced PCAT5 promotes endometrial cancer progression and glycolysis via IGF2BP3 deubiquitination

B Wang, B Wang, J Ma, J He, Z Wang, Q Li… - Cell Death & Disease, 2024 - nature.com
Endometrial cancer (EC) cells exhibit abnormal glucose metabolism, characterized by
increased aerobic glycolysis and decreased oxidative phosphorylation. Targeting cellular …

Ubiquitin-mediated regulation of APE2 protein abundance

A McMahon, J Zhao, S Yan - Journal of Biological Chemistry, 2024 - ASBMB
APE2 plays important roles in the maintenance of genomic and epigenomic stability
including DNA repair and DNA damage response. Accumulating evidence has suggested …

The putative polyamine transporter Shp2 facilitates phosphate export in an Xpr1-independent manner and contributes to high phosphate tolerance

T Komamura, T Nishimura, N Ohta, M Takado… - Journal of Biological …, 2025 - jbc.org
Phosphate (Pi) homeostasis at the cellular level is crucial, requiring coordinated Pi uptake,
storage, and export. However, the regulatory mechanisms, particularly those governing Pi …

Puberty classifications in beef heifers are moderately to highly heritable and associated with candidate genes related to cyclicity and timing of puberty

MK Hess, A Mersha, SS Ference, SR Nafziger… - Frontiers in …, 2024 - frontiersin.org
Introduction: Pubertal attainment is critical to reproductive longevity in heifers. Previously,
four heifer pubertal classifications were identified according to attainment of blood plasma …

[PDF][PDF] Quality and in vitro fertilising ability of cryostored Pinzgau bull insemination doses.

L Olexiková, L Dujíčková, J Vašíček… - Czech Journal of …, 2024 - cjas.agriculturejournals.cz
Applicability of cryopreserved insemination doses is dependent on the quality of the semen
after thawing. The aim of the study was to check the options of new markers for the …