Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …

Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …

Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases,
the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is …

In about half of all human cancers, the tumor suppressor p53 protein is either lost or
mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

The tumor suppressor gene p53 has been implicated in the regulation of epithelial–
mesenchymal transition (EMT) and tumor metastasis by regulating microRNA (miRNA) …