Chemokines modulate immune responses through their ability to orchestrate the migration
of target cells. Chemokines directly induce cell migration through a distinct set of 7 …

As main drivers of leukocyte recruitment during inflammatory reactions, chemokines act as
mediatrs of alarmins in priming host defense responses after tissue exposure to toxic or …

Chemokines are chemotactic cytokines that direct the traffic of leukocytes and other cells in
the body. Chemokines bind to G protein–coupled receptors expressed on target cells to …

IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as
pure decoys or scavengers or trigger dampening of cytokine signaling have been described …

ACRs (atypical chemokine receptors) were initially referred to as 'silent'receptors on the
basis of a lack of signalling and functional activities that are typically observed with …

Chemokines are key mediators of inflammation. In pathological tissues, the main roles of
chemokines are to regulate leucocyte accumulation through the activation of oriented cell …

GPCR proteins represent the largest family of signaling membrane proteins in eukaryotic
cells. Their importance to basic cell biology, human diseases, and pharmaceutical …

Importin-(Imp) β family nucleocytoplasmic transport receptors (NTRs) are supposed to bind
to their cargoes through interaction between a confined interface on an NTR and a nuclear …

Chemokine signalling performs key functions in cell migration via chemoattraction, such as
attracting leukocytes to the site of infection during host defence. The system consists of a …

ABSTRACT InTRODUCTIOn. The imbalance of Th1/Th2 cytokine concentrations and
increased level of IgE might be useful tool for prediction of severity of RSV infection among …