Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

Antigen receptor gene loci are among the most complex in mammals. The IgH locus,
encoding the immunoglobulin heavy chain (IgH) in B-lineage cells, undergoes major …

Homologous recombination, the exchange of DNA strands between homologous DNA
molecules, is involved in repair of many structural diverse DNA lesions. This versatility stems …

Chromatin undergoes major remodeling around DNA double-strand breaks (DSB) to
promote repair and DNA damage response (DDR) activation. We recently reported a high …

High-risk human papillomaviruses (HPVs) are the causative agents of cervical and other
genital cancers. In addition, HPV infections are associated with the development of many …

Cornelia de Lange Syndrome (CdLS) is the founding member of a class of multi-organ
system birth defect syndromes termed cohesinopathies, named for the chromatin-associated …

Ability to reproduce is one of the hallmark features of all life forms by which new organisms
are produced from their progenitors. During this process each cell duplicates its genome …

Human papillomaviruses infect stratified epithelia and link their productive life cycle to the
differentiation state of the host cell. Productive viral replication or amplification is restricted to …

Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world and
is associated with high mortality. Ionizing radiation (IR)‐based therapy causes DNA …

The maintenance of genome integrity is important for normal cellular functions, organism
development and the prevention of diseases, such as cancer. Cellular pathways respond …