The polymyxins are nonribosomal lipopeptides produced by Paenibacillus polymyxa and
are potent antibiotics with activity specifically directed against Gram-negative bacteria. While …

Membrane disruptive α-helical antimicrobial peptides (AMPs) offer an opportunity to address
multidrug resistance; however, most AMPs are toxic and unstable in serum. These …

Pseudomonas aeruginosa, a Gram-negative bacterium, is recognized for its adaptability and
opportunistic nature. It poses a substantial challenge in clinical settings due to its …

We recently showed that solid-phase peptide synthesis using racemic amino acids yields
stereorandomized peptides comprising all possible diastereomers as homogeneous, single …

Trichoderma spp. are ubiquitous rhizosphere fungi capable of producing several classes of
secondary metabolites that can modify the dynamics of the plant-associated microbiome …

The peptidoglycan pathway represents one of the most successful antibacterial targets with
the last critical step being the flipping of carrier lipid, undecaprenyl phosphate (C55-P) …

Bacterial biofilms, often forming on medical devices, can lead to treatment failure due to their
increased antimicrobial resistance. Cefepime-avibactam (CFP-AVI) exhibits potent activities …

The growing incidence of infections caused by multi-drug resistant Gram-negative bacteria
has led to an increased use of last-resort antibiotics such as the polymyxins. Polymyxin …

Bacterial biofilms pose a serious threat to human health, as they prevent the penetration of
antimicrobial agents. Developing nanocarriers that can simultaneously permeate biofilms …

Xinghamide A (1), a new nonapeptide, was discovered in Streptomyces xinghaiensis
isolated from a halophyte, Suaeda maritima (L.) Dumort. Based on high-resolution mass and …