Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …

Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays
major functions in cellular physiology and metabolism as the prosthetic group of diverse …

Emerging scientific evidence has disclosed unsuspected influences between iron
metabolism and type 2 diabetes. The relationship is bi-directional—iron affects glucose …

Numerous pathologies may involve toxic side effects of free heme and heme-derived iron.
Deficiency of the heme-catabolizing enzyme, heme oxygenase-1 (HO-1), in both a human …

Iron is fundamental for life-essential processes. However, it can also cause oxidative
damage, which is thought to trigger numerous pathologies, including cardiovascular …

In the last decade, it has become recognized that reactive oxygen species (ROS) play
important roles in the multiple biological processes involved in the pathophysiology of …

Heme is an essential molecule in aerobic organisms. Heme consists of protoporphyrin IX
and a ferrous (Fe2+) iron atom, which has high affinity for oxygen (O2). Hemoglobin, the …

Objective—We investigated whether red cell infiltration of atheromatous lesions promotes
the later stages of atherosclerosis. Methods and Results—We find that oxidation of ferro …

Atherosclerosis is a chronic inflammatory disease that leads to several acute cardiovascular
complications with poor prognosis. For decades, the role of the adventitial vasa vasorum …