Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies
S Fernbach, NK Mair, IA Abela, K Groen… - Journal of Experimental …, 2024 - rupress.org
Autoantibodies neutralizing type I interferons (IFN-Is) can underlie infection severity. Here,
we trace the development of these autoantibodies at high-resolution using longitudinal …
we trace the development of these autoantibodies at high-resolution using longitudinal …
NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids
CR Simoneau, PY Chen, GK Xing, JM Hayashi… - Scientific Reports, 2024 - nature.com
As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that
recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe …
recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe …
Cost‐effective 3D lung tissue spheroid as a model for SARS‐CoV‐2 infection and drug screening
GASC Miranda, IA Corrêa, ÉA Amorim… - Artificial …, 2024 - Wiley Online Library
Abstract Background The SARS‐CoV‐2 pandemic has spurred an unparalleled scientific
endeavor to elucidate the virus' structure, infection mechanisms, and pathogenesis. Two …
endeavor to elucidate the virus' structure, infection mechanisms, and pathogenesis. Two …
Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology
The emergence of the Omicron lineage represented a major genetic drift in SARS-CoV-2
evolution. This was associated with phenotypic changes including evasion of pre-existing …
evolution. This was associated with phenotypic changes including evasion of pre-existing …