Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment
COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes
only mild symptoms in the majority of the cases, while immunologic complications such as …
only mild symptoms in the majority of the cases, while immunologic complications such as …
[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
RNA editing underlies genetic risk of common inflammatory diseases
A major challenge in human genetics is to identify the molecular mechanisms of trait-
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …
The molecular mechanism of RIG‐I activation and signaling
D Thoresen, W Wang, D Galls, R Guo… - Immunological …, 2021 - Wiley Online Library
RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …
receptor that identifies molecular features common among dsRNA and ssRNA viral …
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms
Summary Severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2) is the
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
Interstitial lung disease in anti-MDA5 positive dermatomyositis
W Wu, L Guo, Y Fu, K Wang, D Zhang, W Xu… - Clinical reviews in …, 2021 - Springer
Anti-melanoma differentiation-associated gene 5–positive dermatomyositis (MDA5+ DM) is
a rare autoimmune disease predominantly reported in East Asia. MDA5+ DM is an …
a rare autoimmune disease predominantly reported in East Asia. MDA5+ DM is an …
The RNA sensor MDA5 detects SARS-CoV-2 infection
Human cells respond to infection by SARS-CoV-2, the virus that causes COVID-19, by
producing cytokines including type I and III interferons (IFNs) and proinflammatory factors …
producing cytokines including type I and III interferons (IFNs) and proinflammatory factors …
NEAT-seq: simultaneous profiling of intra-nuclear proteins, chromatin accessibility and gene expression in single cells
AF Chen, B Parks, AS Kathiria, B Ober-Reynolds… - Nature …, 2022 - nature.com
In this work, we describe NEAT-seq (sequencing of nuclear protein epitope abundance,
chromatin accessibility and the transcriptome in single cells), enabling interrogation of …
chromatin accessibility and the transcriptome in single cells), enabling interrogation of …