In the last few decades, traditional natural products have been the center of attention for the
scientific community and exploration of their therapeutic abilities is proceeding perpetually …

Introduction: Type 2 diabetes mellitus and hypercholesterolemia have proven to give an
increased incidence of cardiovascular diseases (CVD). Recent studies have suggested that …

Functional wound dressing with tailored physicochemical and biological properties is vital
for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to …

Liver cirrhosis is a form of liver fibrosis resulting from chronic hepatitis caused by various
liver diseases, such as viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis …

Aims Berberine, a botanical alkaloid purified from Coptidis rhizoma, is reported to activate
the AMP-activated protein kinase (AMPK). Whether AMPK is required for the protective …

Oxidative stress and amplified redox signaling contribute to the pathogenesis of many
human diseases including atherosclerosis. The superoxide-generating phagocytic NADPH …

Inflammation is central to the pathogenesis of acute coronary syndrome (ACS) and is
associated with adverse clinical outcomes after percutaneous coronary intervention (PCI) …

Berberine is one of the main alkaloids found in the Chinese herb Huang lian (Rhizoma
Coptidis), which has been reported to have multiple pharmacological activities. This study …

BACKGROUND: Overproduction of MMPs (matrix metalloproteinases) and EMMPRIN
(extracellular matrix metalloproteinase inducer) by monocytes/macrophages leads to …

Coptidis rhizoma (Coptis) and its alkaloids exert various pharmacological functions in cells
and tissues; however, the oral absorption of these alkaloids requires further elucidation. The …