[HTML][HTML] Acyl-CoA: diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control

G Chen, JL Harwood, MJ Lemieux, SJ Stone… - Progress in Lipid …, 2022 - Elsevier
Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

Mechanisms of intestinal triacylglycerol synthesis

SJ Stone - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2022 - Elsevier
Triacylglycerols are a major source of stored energy that are obtained either from the diet or
can be synthesized to some extent by most tissues. Alterations in pathways of triacylglycerol …

[HTML][HTML] BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells

T Rossi, R Zamponi, M Chirico, ME Pisanu… - Journal of Experimental …, 2023 - Springer
Abstract Background Triple-Negative Breast Cancer (TNBC) is a subtype of breast cancer
that differs from other types of breast cancers in the faster spread and worse outcome. TNBC …

[HTML][HTML] DGAT1 inhibitor suppresses prostate tumor growth and migration by regulating intracellular lipids and non-centrosomal MTOC protein GM130

F Nardi, OE Franco, P Fitchev, A Morales… - Scientific reports, 2019 - nature.com
Acyl-CoA: diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which is
increased in metabolically active cells to meet nutrient requirements. DGAT1 has been …

[HTML][HTML] Genome wide association study identifies novel potential candidate genes for bovine milk cholesterol content

DN Do, FS Schenkel, F Miglior, X Zhao… - Scientific reports, 2018 - nature.com
This study aimed to identify single nucleotide polymorphisms (SNPs) associated with milk
cholesterol (CHL) content via a genome wide association study (GWAS). Milk CHL content …

[HTML][HTML] Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis

M Duta-Mare, V Sachdev, C Leopold, D Kolb… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Lysosomal acid lipase (LAL) is the only known enzyme, which hydrolyzes cholesteryl esters
and triacylglycerols in lysosomes of multiple cells and tissues. Here, we explored the role of …

The TICE Pathway: Mechanisms and Potential Clinical Applications

H Xu, Y Xin, J Wang, Z Liu, Y Cao, W Li, Y Zhou… - Current Atherosclerosis …, 2023 - Springer
Abstract Purpose of Review Transintestinal cholesterol excretion (TICE) is a non-biliary
pathway that excretes excess cholesterol from the body through feces. This article focuses …

Developments in intestinal cholesterol transport and triglyceride absorption

Y Paalvast, JF De Boer, AK Groen - Current opinion in lipidology, 2017 - journals.lww.com
The importance of the intestine in control of cholesterol and triglyceride homeostasis is
increasingly recognized. Recently, novel factors involved in regulation of cholesterol …

Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action

L Wang, H Wang, J Niu, H Chen, M Wang… - European Journal of …, 2024 - Elsevier
Rhubarb free anthraquinones (RhA) have significant lipid-regulating activity. However,
whether RhA monomers have a role in lipid-regulating and their mechanism of action …

[HTML][HTML] Hepatic synthesis of triacylglycerols containing medium-chain fatty acids is dominated by diacylglycerol acyltransferase 1 and efficiently inhibited by etomoxir

K Wunderling, C Leopold, I Jamitzky, M Yaghmour… - Molecular …, 2021 - Elsevier
Objective Medium-chain fatty acids (MCFAs) play an increasing role in human nutrition. In
the liver, one fraction is used for synthesis of MCFA-containing triacylglycerol (MCFA-TG) …