The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the
steroidogenic cells of the adrenal, gonad, placenta and brain contain the cholesterol side …

Inter-organelle membrane contacts sites (MCSs) are specific subcellular regions favoring
the exchange of metabolites and information. We investigated the potential role of the late …

Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …

Adrenal gonadal, placental and brain mitochondria contain several steroidogenic enzymes,
notably the cholesterol side chain cleavage enzyme, P450scc, which is the enzymatic rate …

All animal subcellular membranes require cholesterol, which influences membrane fluidity
and permeability, fission and fusion processes, and membrane protein function. The …

We review the cellular mechanisms implicated in cholesterol trafficking and distribution.
Recent studies have provided new information about the distribution of sterols within cells …

Recent studies have revealed the existence of numerous contact sites between the
endoplasmic reticulum (ER) and endosomes in mammalian cells. Such contacts increase …

Publisher Summary This chapter focuses on the techniques used for ecdysteroid analysis
and the biosynthesis and metabolism of these hormones. Ecdysteroids could be defined …