The vaginal mucosa is commonly exposed to a variety of topical agents, including chemical
contraceptives, drugs for the treatment of specific pathological conditions, and pathogenic …

The vagina stands as an important alternative to the oral route for those systemic drugs that
are poorly absorbed orally or are rapidly metabolized by the liver. Drug permeation through …

The scarcity of sizeable specimens of normal oral mucosa for experimental purposes has
hampered research on oral epithelium. Because large specimens of viable human vaginal …

The effect of various in vitro conditions on the permeability characteristics of the buccal
mucosa was assessed using caffeine (CAF) and estradiol (E 2) as model hydrophilic and …

Transbuccal drug delivery has got several well-known advantages especially with respect to
peroral way. Since a major limitation in buccal drug delivery could be the low permeability of …

Porcine buccal mucosa has been used as an in vitro model to assess the potential of
delivering a molecule via the transbuccal route. However, permeation studies across …

Skin is commonly stored frozen and then thawed prior to use for in vitro permeation
experiments. Does frozen storage of skin alter its barrier property? Numerous studies have …

A number of drugs undergo extensive first-pass metabolism after oral administration,
necessitating large doses for effective therapeutic responses in the body. Buccal …

Purpose. To investigate the permeation of cyclosporin A (CsA) through fresh and frozen
human corneas in the presence and absence of three penetration enhancers: benzalkonium …

The buccal mucosa serves as an attractive site for the systemic delivery of many drugs,
including peptides and proteins, because of its inherent permeability and the avoidance of …