Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
The RNA-binding motif protein family in cancer: friend or foe?
Z Li, Q Guo, J Zhang, Z Fu, Y Wang, T Wang… - Frontiers in …, 2021 - frontiersin.org
The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named,
containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein …
containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein …
Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion
Classical Hodgkin lymphoma (cHL) is composed of rare malignant Hodgkin Reed-Sternberg
(HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS …
(HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS …
Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1–SREBP pathway
Abstract p53 is known to modulate metabolism and FDXR is required for steroidogenesis.
Given that FDXR is a target/regulator of p53, the FDXR–p53 axis may play a unique role in …
Given that FDXR is a target/regulator of p53, the FDXR–p53 axis may play a unique role in …
Genomic landscape of Hodgkin lymphoma
MM Brune, D Juskevicius, J Haslbauer, S Dirnhofer… - Cancers, 2021 - mdpi.com
Simple Summary Hodgkin lymphoma (HL) is composed of many reactive and only a few
cancer cells, so-called Hodgkin and Reed-Sternberg (HRS) or lymphocyte predominant (LP) …
cancer cells, so-called Hodgkin and Reed-Sternberg (HRS) or lymphocyte predominant (LP) …
Construction of an RNA-binding protein-related prognostic model for pancreatic adenocarcinoma based on TCGA and GTEx databases
X Wen, Z Shao, S Chen, W Wang, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Background: Recently, RNA-binding proteins (RBPs) were reported to interact with target
mRNA to regulate gene posttranscriptional expression, and RBP-mediated RNA …
mRNA to regulate gene posttranscriptional expression, and RBP-mediated RNA …
TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer
T Zhong, J Zhang, X Liu, H Li - Cellular Oncology, 2023 - Springer
Cisplatin (CDDP)-based chemotherapy is commonly used to treat advanced non-small cell
lung cancer (NSCLC). However, the efficacy is limited by the development of drug …
lung cancer (NSCLC). However, the efficacy is limited by the development of drug …
Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1
J Zhang, W Sun, X Kong, Y Zhang… - Proceedings of the …, 2019 - National Acad Sciences
p53 is the most frequently mutated gene in human cancers and mutant p53 has a gain of
function (GOF) that promotes tumor progression and therapeutic resistance. One of the …
function (GOF) that promotes tumor progression and therapeutic resistance. One of the …
KPNA2-associated immune analyses highlight the dysregulation and prognostic effects of GRB2, NRAS, and their RNA-binding proteins in hepatocellular carcinoma
X Zhang, J Zhang, F Gao, S Fan, L Dai… - Frontiers in genetics, 2020 - frontiersin.org
Karyopherin α2 (KPNA2) was reported to be overexpressed and have unfavorable
prognostic effects in many malignancies including hepatocellular carcinoma (HCC) …
prognostic effects in many malignancies including hepatocellular carcinoma (HCC) …
RBM38 in cancer: role and mechanism
Cancer is the second leading cause of death globally. Abnormity in gene expression
regulation characterizes the trajectory of tumor development and progression. RNA-binding …
regulation characterizes the trajectory of tumor development and progression. RNA-binding …