The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …

Manufacturing of powder-based products is a focus of increasing research in the recent
years. The main reason is the lack of predictive process models connecting process …

Three-dimensional (3-D) population balance equations are often used to model wet
granulation processes, simulating distributions in particle size, liquid binder content, and …

In this work, a dynamic flowsheet model for the production of pharmaceutical tablets through
a continuous wet granulation process is developed. The unit operation models which are …

This study is concerned with the development of a novel population balance model (PBM)
framework that can qualitatively capture the dynamics of a continuous powder mixing …

In the recent few years, continuous processing has been considered as a promising process
alternative to batch processing in pharmaceutical manufacturing. Via a novel population …

This paper focuses on obtaining the numerical solution to a three-dimensional population
balance model (PBM) of granulation using the cell-average technique first proposed by [22] …

It has been recognized that the application of quality by design (QbD) to continuous
processing in the pharmaceutical industry leads to better process control, improved product …

As the pharmaceutical industry seeks more efficient methods for the production of higher
value therapeutics, the associated data analysis, data visualization, and predictive modeling …

This work is concerned with the theoretical development of a semi-mechanistic aggregation
kernel in a population balance model (PBM) which takes into account the effect of droplet …