The transient receptor potential (TRP) multigene superfamily encodes integral membrane
proteins that function as ion channels. Members of this family are conserved in yeast …

Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …

Numerous physiological functions rely on distinguishing temperature through temperature-
sensitive transient receptor potential channels (thermo-TRPs). Although the function of …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Allyl isothiocyanate, the pungent principle of wasabi and other mustard oils, produces pain
by activating TRPA1, an excitatory ion channel on sensory nerve endings. Isothiocyanates …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

The abilities to sense environmental and internal temperatures are required for survival,
both for maintenance of homeostasis and for avoidance of tissue-damaging noxious …

The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …

In mammals and birds, thermoregulation to conserve body temperature is vital to life.
Multiple mechanisms of thermogeneration have been proposed, localized in different …

Transient receptor potential (TRP) proteins form plasma-membrane cation channels that act
as sensors for diverse cellular stimuli. Here, we report a novel activation mechanism …