Neuroplasticity underlying the comorbidity of pain and depression

L Doan, T Manders, J Wang - Neural plasticity, 2015 - Wiley Online Library
Acute pain induces depressed mood, and chronic pain is known to cause depression.
Depression, meanwhile, can also adversely affect pain behaviors ranging from …

Emotional consequences of neuropathic pain: insight from preclinical studies

I Yalcin, F Barthas, M Barrot - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain, including neuropathic pain. While this comorbidity is clinically …

Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation

KE Hannibal, MD Bishop - Physical therapy, 2014 - academic.oup.com
Pain is a primary symptom driving patients to seek physical therapy, and its attenuation
commonly defines a successful outcome. A large body of evidence is dedicated to …

Neurosteroids: mechanistic considerations and clinical prospects

JL Maguire, S Mennerick - Neuropsychopharmacology, 2024 - nature.com
Like other classes of treatments described in this issue's section, neuroactive steroids have
been studied for decades but have risen as a new class of rapid-acting, durable …

Burnout phenomenon: neurophysiological factors, clinical features, and aspects of management

RAG Khammissa, S Nemutandani… - Journal of …, 2022 - journals.sagepub.com
Burnout syndrome is a distinct “occupational phenomenon” rather than a medical condition,
comprising emotional exhaustion, physical fatigue, and cognitive weariness. Both …

Structural changes of the brain in relation to occupational stress

I Savic - Cerebral Cortex, 2015 - academic.oup.com
Despite mounting reports about the negative effects of chronic occupational stress on
cognitive functions, it is still uncertain whether and how this type of stress is associated with …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

[HTML][HTML] Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

G Perlman, A Tanti, N Mechawar - Neurobiology of stress, 2021 - Elsevier
Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …

Short environmental enrichment in adulthood reverses anxiety and basolateral amygdala hypertrophy induced by maternal separation

AS Koe, A Ashokan, R Mitra - Translational Psychiatry, 2016 - nature.com
Maternal separation during early childhood results in greater sensitivity to stressors later in
adult life. This is reflected as greater propensity to develop stress-related disorders in …

Stress hypothesis overload: 131 hypotheses exploring the role of stress in tradeoffs, transitions, and health

BN Harris - General and Comparative Endocrinology, 2020 - Elsevier
Stress is ubiquitous and thus, not surprisingly, many hypotheses and models have been
created to better study the role stress plays in life. Stress spans fields and is found in the …