Familial disorders of skeletal muscle excitability were initially described early in the last
century and are now known to be caused by mutations of voltage-gated ion channels. The …

Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …

A deficiency of Ca2+ fluxes arising from dysfunctional voltage-gated calcium channels has
been associated with a list of calcium channelopathies such as epilepsy, hypokalemic …

Dystonias comprise a group of movement disorders that are characterized by involuntary
movements and postures. Insight into the nature of neuronal dysfunction has been provided …

Paroxysmal dyskinesias are episodic movement disorders that can be inherited or are
sporadic in nature. The pathophysiology underlying these disorders remains largely …

Ion channelopathies are inherited diseases in which alterations in control of ion
conductance through the central pore of ion channels impair cell function, leading to …

Voltage-activated sodium (Nav) channels are crucial for the generation and propagation of
nerve impulses, and as such are widely targeted by toxins and drugs. The four voltage …

The non-dystrophic myotonias are an important group of skeletal muscle channelopathies
electrophysiologically characterized by altered membrane excitability. Many distinct clinical …

Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis
sativa, which has been proposed to be therapeutic against many conditions, including …

Gain-of-function mutations or dysregulated expression of voltage-gated sodium channels
can produce neuronal hyperexcitability, leading to acute or chronic pain. The sodium …