Transfer RNA (tRNA) is structurally unique among nucleic acids in harboring an astonishing
diversity of post-transcriptionally modified nucleoside. Two of the most radically modified …

Transfer RNA–guanine transglycosylases (TGTs) are evolutionarily ancient enzymes,
present in all kingdoms of life, catalyzing guanine exchange within their cognate tRNAs by …

This graduate textbook is aimed at providing researchers new to the subject with information
on the structure and mechanisms in the chemistry, biochemistry or processing of …

Riboswitches are RNA regulatory elements that govern gene expression by recognition of
small molecule ligands via a high affinity aptamer domain. Molecular recognition can lead to …

We demonstrate the site-specific incorporation of nucleobase derivatives bearing
fluorophores or affinity labels into a short RNA stem loop recognition motif by exchange of a …

The enzyme YkvM from Bacillus subtilis was identified previously along with three other
enzymes (YkvJKL) in a bioinformatics search for enzymes involved in the biosynthesis of …

In tRNAAsp, tRNAAsn, tRNATyr, and tRNAHis of most bacteria and eukaryotes, the
anticodon wobble position may be occupied by the modified nucleoside queuosine, which …

tRNA guanine transglycosylase (TGT) enzymes are responsible for the formation of
queuosine in the anticodon loop (position 34) of tRNA Asp, tRNA Asn, tRNA His, and tRNA …

Eubacterial tRNA-guanine transglycosylase (TGT) is involved in the hyper-modification of
cognate tRNAs leading to the exchange of G34 at the wobble position in the anticodon loop …

Queuosine is a hypermodified nucleoside found in position 34, the anticodon wobble
position, of four tRNA species. This modification is distributed with near uniformity across all …