Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

The sustained proliferation of microglia is a key hallmark of Alzheimer's disease (AD),
accelerating its progression. Here, we aim to understand the long-term impact of the early …

Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex,
poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and …

Microglial activation is a distinguished attribute in many neurodegenerative diseases of
aging. Compelling evidence suggests that neuroinflammation stimulated by microglia, the …

Intranasal insulin (INI) has shown promise as a treatment for Alzheimer's disease (AD) in
pilot clinical trials. In a recent phase 2 trial, participants with mild cognitive impairment (MCI) …

The inflammatory response that marks Alzheimer's disease (neuroinflammation) is
considered a double-edged sword. Microglia have been shown to play a protective role at …

Tauopathies are neurodegenerative diseases which course with the accumulation of Tau,
mainly in neurons. In addition, Tau accumulates in a hyperphosphorylated and aggregated …

Glial cells are multifunctional, non-neuronal components of the central nervous system with
diverse phenotypes that have gained much attention for their close involvement in …