The evolution and clinical impact of hepatitis B virus genome diversity
The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
Safety, pharmacokinetics, and antiviral effects of ABI-H0731, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial
Background Therapies with novel mechanisms of action against hepatitis B virus (HBV)
infection are being explored with the goal of achieving a functional cure (sustained off …
infection are being explored with the goal of achieving a functional cure (sustained off …
Safety, pharmacokinetics, and antiviral activity of RO7049389, a core protein allosteric modulator, in patients with chronic hepatitis B virus infection: a multicentre …
Background RO7049389, a hepatitis B virus (HBV) core protein allosteric modulator being
developed for the treatment of chronic HBV infection, was found to be safe and well tolerated …
developed for the treatment of chronic HBV infection, was found to be safe and well tolerated …
[HTML][HTML] Safety and efficacy of vebicorvir administered with entecavir in treatment-naïve patients with chronic hepatitis B virus infection
MS Sulkowski, K Agarwal, X Ma, TT Nguyen… - Journal of …, 2022 - Elsevier
Background & Aims Nucleos (t) ide reverse transcriptase inhibitors do not completely
suppress HBV DNA in chronic HBV infection (cHBV). Vebicorvir (VBR) is an investigational …
suppress HBV DNA in chronic HBV infection (cHBV). Vebicorvir (VBR) is an investigational …
HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA
polymerase into nucleocapsids for reverse transcriptional DNA replication to take place …
polymerase into nucleocapsids for reverse transcriptional DNA replication to take place …
Novel potent capsid assembly modulators regulate multiple steps of the hepatitis B virus life cycle
T Lahlali, JM Berke, K Vergauwen, A Foca… - Antimicrobial agents …, 2018 - Am Soc Microbiol
The assembly of hepatitis B virus (HBV) core protein (HBc) into capsids represents a critical
step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it …
step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it …
Novel Anti-Hepatitis B Virus Activity of Euphorbia schimperi and Its Quercetin and Kaempferol Derivatives
MK Parvez, S Ahmed, MS Al-Dosari… - ACS …, 2021 - ACS Publications
Natural or plant products, because of their structural diversity, are a potential source for
identifying new anti-hepatitis B virus (HBV) agents. Here, we report the anti-HBV activity of …
identifying new anti-hepatitis B virus (HBV) agents. Here, we report the anti-HBV activity of …
Preclinical profile and characterization of the hepatitis B virus core protein inhibitor ABI-H0731
ABSTRACT ABI-H0731, a first-generation hepatitis B virus (HBV) core protein inhibitor, has
demonstrated effective antiviral activity in chronic hepatitis B (CHB) patients in a phase 1b …
demonstrated effective antiviral activity in chronic hepatitis B (CHB) patients in a phase 1b …
[HTML][HTML] Bioassay-guided isolation of anti-hepatitis B virus flavonoid myricetin-3-O-rhamnoside along with quercetin from Guiera senegalensis leaves
Recently, we have shown in vitro anti-hepatitis B virus (HBV) activity of G. senegalensis JF
Gmel leaves, and Identified quercetin and other flavonoids by HPTLC. Here we report …
Gmel leaves, and Identified quercetin and other flavonoids by HPTLC. Here we report …