As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Tail-anchored (TA) proteins fulfill diverse cellular functions within different organellar
membranes. Their characteristic C-terminal transmembrane segment renders TA proteins …

Hundreds of nucleus‐encoded mitochondrial precursor proteins are synthesized in the
cytosol and imported into mitochondria in a post‐translational manner. However, the early …

Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into
mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the …

Mitochondrial biogenesis requires the import of> 1,000 mitochondrial preproteins from the
cytosol. Most studies on mitochondrial protein import are focused on the core import …

Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy.
However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, are …

The abundance of each cellular protein is dynamically adjusted to the prevailing metabolic
and stress conditions by modulation of their synthesis and degradation rates. The …

Mitochondrial protein import Mitochondria contain 902 (yeast) to 1.136 (mouse, humans)
verified proteins. Except for a very small number of mitochondrially encoded core …

Mitochondria contain two membranes, the outer and inner membrane. The outer membrane
fulfills crucial functions for the communication of mitochondria with the cellular environment …

Mitochondria are organelles indispensable for the correct functioning of eukaryotic cells.
Their significance for cellular homeostasis is manifested by the existence of complex quality …