Caenorhabditis elegans is a small free-living nematode that lives in temperate soil
environments. It has been widely employed as an animal model in research involving …

As a model organism that has helped revolutionize life sciences, Caenorhabditis elegans
has been increasingly used in nutrition research. Here we explore the tradeoffs between …

Chronic inflammation predisposes to aging-associated disease, but it is unknown whether
immunity regulation might be important for extending healthy lifespan. Here we show that in …

Lonicera japonica (LJ) is widely used as the local medicine to improve body and prevent ills
in China, but mechanisms of its healthy beneficial effects remain largely unclear. Here, we …

Diet is one of the more variable aspects in life due to the variety of options that organisms
are exposed to in their natural habitats. In the laboratory, C. elegans are raised on bacterial …

Sensations of the internal state of the body play crucial roles in regulating the physiological
processes and maintaining homeostasis of an organism. However, our understanding of …

Caloric restriction (CR), a reduction in calorie intake without malnutrition, retards aging in
several animal models from worms to mammals. Developing CR mimetics, compounds that …

Longevity mechanisms increase lifespan by counteracting the effects of aging. However,
whether longevity mechanisms counteract the effects of aging continually throughout life, or …

Virtually all age-related neurodegenerative diseases (NDs) can be characterized by the
accumulation of proteins inside and outside the cell that are thought to significantly …

Energy metabolism becomes dysregulated in individuals with obesity and many of these
changes persist after weight loss and likely play a role in weight regain. In these studies, we …