Nanoparticles are often engineered as a scaffolding system to combine targeting, imaging
and/or therapeutic moieties into a unitary agent. However, mostly overlooked, the …

Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of
different materials and adjustment of their physical and chemical properties, nanoparticles …

Background & aims In celiac disease (CeD), gluten induces immune activation, leading to
enteropathy. TAK-101, gluten protein (gliadin) encapsulated in negatively charged poly (dl …

Polymers, lipids, scaffolds, microneedles, and other biomaterials are rapidly emerging as
technologies to improve the efficacy of vaccines against infectious disease and …

Background & Aims Celiac disease could be treated, and potentially cured, by restoring T-
cell tolerance to gliadin. We investigated the safety and efficacy of negatively charged 500 …

A large body of evidence that has accumulated over the past decade strongly supports the
role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory …

Autoimmune diseases affect roughly 5-10% of the total population, with women affected
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …

Polymeric nanomaterials have become a prominent area of research in the field of drug
delivery. Their application in nanomedicine can improve bioavailability, pharmacokinetics …

Aerosolization of immunotherapies poses incredible potential for manipulating the local
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …

Nanoparticles (NPs) can be used to accomplish antigen-specific immune tolerance in
allergic and autoimmune disease. The available options for custom-designing tolerogenic …