Clustered regularly interspersed short pallindromic repeats (CRISPR) and CRISPR
associated proteins (Cas) system (CRISPR-Cas) came into light as prokaryotic defence …

Synthetic biology has mainly focused on introducing new or altered functionality in single
cell systems: primarily bacteria, yeast, or mammalian cells. Here, we describe the extension …

The requirement for Cas nucleases to recognize a specific PAM is a major restriction for
genome editing. SpCas9 variants SpG and SpRY, recognizing NGN and NRN PAMs …

RNA passed from parents to progeny controls several aspects of early development. The
germline of the free-living nematode Caenorhabditis elegans contains many families of …

Mitochonic Acid 5 (MA-5) enhances mitochondrial ATP production, restores fibroblasts from
mitochondrial disease patients and extends the lifespan of the disease model “Mitomouse” …

As a tool for modifying the genome, gene editing technology has developed rapidly in recent
years, especially in the past two years. With the emergence of new gene editing …

Development of the Caenorhabditis elegans reproductive tract is orchestrated by the anchor
cell (AC). This occurs in part through a cell invasion event that connects the uterine and …

The increase in our molecular understanding of the biology of aging, coupled with a recent
surge in investment, has led to the formation of several companies developing …

基因编辑是一种能够进行基因组修饰的基因工程技术. 近年来, 随着分子生物学技术的飞速发展,
成簇规则间隔短回文重复序列相关蛋白系统(clustered regularly interspaced short palindromic …

Gene regulation has been studied in C. elegans for over 30 years. In this analysis of 102
publications, we find that most transcriptional cis-regulatory elements are located within …