General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …

Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that
now spans 35 years of research. While all neurotrophins share considerable overlap in …

Various experimental studies in animals have shown that general anaesthetics are
potentially toxic to the developing brain. By inducing apoptosis or interfering with …

Since their first use, anaesthetic agents have seen major advancements and are now an
indispensable element of surgical procedures. Two of the most used volatile anaesthetics …

Anesthetics that permit surgical procedures and stressful interventions have been found to
cause structural brain abnormalities and functional impairment in immature animals …

Anesthesia kills neurons in the brain of infantile animals, including primates, and causes
permanent and progressive neurocognitive decline. The anesthesia community and …

Background Propofol exposure to neurons during synaptogenesis results in apoptosis,
leading to cognitive dysfunction in adulthood. Previous work from our laboratory showed that …

Background: General anesthetics induce apoptotic neurodegeneration in the developing
mammalian brain. General anesthesia (GA) also causes significant disturbances in …

General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission
principally by modulating the function of glutamatergic or GABAergic synapses, respectively …

Various lines of evidence suggest that neonatal exposure to general anesthetics, especially
repeatedly, results in neuropathological brain changes and long‐term cognitive impairment …