One of the major advances in medical science has been the development of antimicrobials;
however, a consequence of their widespread use has been the emergence of drug-resistant …

Nucleic acid molecules play crucial roles in diverse biological processes including the
storage, transport, processing, and expression of the genetic information. Nucleic acid …

Understanding the molecular mechanisms underlying synergistic, potentiative and
antagonistic effects of drug combinations could facilitate the discovery of novel efficacious …

We have used the recently determined atomic structure of the 30S ribosomal subunit to
determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and …

Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections
for the past half century. Whereas the interest in these versatile antibiotics continues to be …

Aminoglycosides are among the most commonly used broad-spectrum antibiotics in the anti-
infective armamentarium. The vast majority of aminoglycosides are bactericidal, they have …

Following the discovery of penicillin, which was inactive against Mycobacterium
tuberculosis, Waksman discovered the first antituberculosis agent, streptomycin, by …

Many clinically useful antibiotics exert their antimicrobial effects by blocking protein
synthesis on the bacterial ribosome. The structure of the ribosome has recently been …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

The development of small molecules that target RNA is challenging yet, if successful, could
advance the development of chemical probes to study RNA function or precision …