Membrane contact sites emerged in the last decade as key players in the integration,
regulation and transmission of many signals within cells, with critical impact in multiple …

Abstract CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease
Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder …

NEET proteins belong to a highly conserved group of [2Fe–2S] proteins found across all
kingdoms of life. Due to their unique [2Fesingle bond2S] cluster structure, they play a key …

Background LPS-inhibited osteoblastic differentiation plays an important role in the
pathogenesis of osteomyelitis. Thus, searching for drugs that affect LPS-mediated …

Abstract The CISD2 (NAF-1) protein plays a key role in regulating cellular homeostasis,
aging, cancer and neurodegenerative diseases. It was found to control different calcium …

Bone mass loss around prostheses is a major cause of implant failure, especially in
postmenopausal osteoporosis patients. In osteoporosis, excess oxidative stress largely …

Wolfram syndrome (WS) is a rare neurodegenerative disease, the main pathological
hallmarks of which associate with diabetes, optic atrophy, and deafness. Other symptoms …

Osteogenic differentiation is crucial for the maintenance of bone homeostasis. Sirtuin 3
(SIRT3), a member of sirtuins family, functions as a critical deacetylase that regulates many …

Abstract LP Li, L. Venkataraman, S. Chen, and HJ Fu. Function of WFS1 and WFS2 in the
Central Nervous System: Implications for Wolfram Syndrome and Alzheimer's Disease …

Elevated levels of mitochondrial iron and reactive oxygen species (ROS) accompany the
progression of diabetes, negatively impacting insulin production and secretion from …