[HTML][HTML] Liquid‒liquid phase separation: roles and implications in future cancer treatment
Z Liu, Z Qin, Y Liu, X Xia, L He, N Chen… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Liquid‒liquid phase separation (LLPS) is a phenomenon driven by weak interactions
between biomolecules, such as proteins and nucleic acids, that leads to the formation of …
between biomolecules, such as proteins and nucleic acids, that leads to the formation of …
Transcriptional condensates and phase separation: condensing information across scales and mechanisms
Transcription is the fundamental process of gene expression, which in eukaryotes occurs
within the complex physicochemical environment of the nucleus. Decades of research have …
within the complex physicochemical environment of the nucleus. Decades of research have …
Molecular basis of ligand-dependent Nurr1-RXRα activation
X Yu, J Shang, DJ Kojetin - Elife, 2023 - elifesciences.org
Small molecule compounds that activate transcription of Nurr1-retinoid X receptor alpha
(RXRα)(NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of …
(RXRα)(NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of …
Exploiting the DNA Damage Response for Prostate Cancer Therapy
Simple Summary Localized prostate cancer has a favorable prognosis and can be
effectively treated with radiotherapy, as well as therapies that target hormone production and …
effectively treated with radiotherapy, as well as therapies that target hormone production and …