The following brief summary is based on a recent wx review by Rubin and Baserga 1, and
the reader is referred to that review for extended references. A simplified representation of …

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine
Action Page 1 The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin …

The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like
growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti …

The type 1 insulin-like growth factor receptor (IGF-IR) sends several signals, some of which
are contradictory. When the concentrations of insulin receptor substrate 1 (IRS-1), a major …

Cross-talk between insulin-like growth factor (IGF)-and estrogen receptor (ER)-signaling
pathways results in synergistic growth. We show here that estrogen enhances IGF signaling …

Abstract The Insulin Receptor Substrate (IRS) proteins are cytoplasmic adaptor proteins that
function as essential signaling intermediates downstream of activated cell surface receptors …

Glioblastomas frequently carry mutations in the PTEN tumor suppressor gene on 10q23. 3.
The tumor suppressor properties of Pten are closely related to its inhibitory effect on the …

The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal
and abnormal growth. It is particularly important in anchorage-independent growth …

Recent genetic studies have documented a pivotal growth-regulatory role played by the
Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting …

In recent years, the type 1 insulin-like growth factor receptor (IGF-IR) has emerged as a
receptor that plays a very important role in the growth of cells, both in vivo and in vitro. The …