Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …

Phosphodiesterase 4 (PDE4) enzymes catalyze cyclic adenosine monophosphate (cAMP)
hydrolysis and are involved in a variety of physiological processes, including brain function …

Chronic social isolation stress during adolescence induces susceptibility for
neuropsychiatric disorders. Here we show that 5-week post-weaning isolation stress …

Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of
histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase …

Emerging evidence from genomics, post-mortem, and preclinical studies point to a potential
dysregulation of molecular signaling at postsynaptic density (PSD) in schizophrenia …

Irritability, a state of excessive reactivity to negative emotional stimuli, is common in
individuals with autism spectrum disorder (ASD). Although it has a significant negative …

Neurodevelopmental disorders (NDDs) such as intellectual disability and autism spectrum
disorder consistently show a male bias in prevalence, but it remains unclear why males and …

The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved
multiprotein complex that comprises neurotransmitter receptors, cell‐adhesion molecules …

Digging behavior is often used to test motor function and repetitive behaviors in mice.
Different digging paradigms have been developed for behaviors related to anxiety and …