Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to
membrane traffic,. Among the seven eukaryotic phosphoinositides the best studied species …

The endocytic network comprises a series of interconnected tubulo-vesicular membranous
compartments that together regulate various sorting and signalling events. Although it is …

Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing …

The internalization and subsequent endosomal trafficking of proteins and membrane along
the endocytic pathway is a fundamental cellular process. Over the last two decades, this …

Lysosomes are essential organelles that function to degrade and recycle unwanted,
damaged and toxic biological components. Lysosomes also act as signalling platforms in …

The membrane remodeling events required for autophagosome biogenesis are still poorly
understood. Because PX domain proteins mediate membrane remodeling and trafficking …

The GTPase dynamin is essential for CME (clathrin-mediated endocytosis), but its exact
function and mechanism of action have been controversial. Here, we review findings that …

Peripheral membrane proteins of the Bin/amphiphysin/Rvs (BAR) and Fer-CIP4 homology-
BAR (F-BAR) family participate in cellular membrane trafficking and have been shown to …