The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …

Twenty years after the initial description of a tissue engineered construct, 3-dimensional
human cardiac tissues of different kinds are now generated routinely in many laboratories …

Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

Cardiac troponin I (cTnI) is a key regulatory protein in cardiac muscle contraction and
relaxation, linking Ca2+–troponin C binding with activation of crossbridge reactions with the …

We develop a point model of the cardiac myofilament (MF) to simulate a wide variety of
experimental muscle characterizations including Force-Ca relations and twitches under …

The determinants of relaxation in cardiac muscle are poorly understood, yet compromised
relaxation accompanies various pathologies and impaired pump function. In this study, we …

An intricate network of reactions is involved in matching energy supply with demand in the
heart. This complexity arises because energy production both modulates and is modulated …

Objective Reactive oxygen species (ROS) have been implicated in the progression of
ventricular hypertrophy to congestive heart failure. However, the source of increased …

We propose four novel mathematical models, describing the microscopic mechanisms of
force generation in the cardiac muscle tissue, which are suitable for multiscale numerical …

Acute β-adrenergic stimulation enhances cardiac contractility, accelerates muscle
relaxation, and amplifies the inotropic and lusitropic response to increased stimulation …