Mycobacterium tuberculosis is a globally distributed, lethal pathogen of humans. The
virulence armamentarium of M. tuberculosis appears to have been developed on a scaffold …

Mycobacterium tuberculosis (Mtb) is the causative pathogen of tuberculosis, the most lethal
infectious disease resulting in 1.3 million deaths annually. Treatments against Mtb are …

Human and animal tuberculosis is caused by the Mycobacterium tuberculosis Complex
(MTBC), which has evolved a genomic decay of cobalamin (vitamin B12) biosynthetic …

Some of the most dangerous bacterial pathogens (Gram-negative and mycobacterial)
deploy a formidable secondary membrane barrier to reduce the influx of exogenous …

Successful colonization of the host requires Mycobacterium tuberculosis (Mtb) to sense and
respond coordinately to disparate environmental cues during infection and adapt its …

Background Increasing prevalence of drug-resistant tuberculosis (DR-TB) poses a major
challenge to the early detection and effective control of tuberculosis (TB). Exosomes carrying …

Steroids are abundant molecules in nature, and various microorganisms evolved to utilize
steroids. Thermophilic actinobacteria play an important role in such processes. However …

Understanding the complex mechanisms of mycobacterial pathophysiology and adaptive
responses presents challenges that can hinder drug development. However, employing …

Many studies have identified host-derived lipids, characterised by the abundance of
cholesterol, as a major source of carbon nutrition for Mycobacterium tuberculosis during …

The ability of Mycobacterium tuberculosis to remain dormant after primary infection
represents the prime cause of new TB cases throughout the world. Hence, diagnosis and …