Cancer is a devastating disease and is the second leading cause of death worldwide.
Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment of choice for …

Cancer cells frequently develop resistance to chemotherapeutic therapies and targeted
drugs, which has been a significant challenge in cancer management. With the growing …

Background: Elevated APOBEC3B expression in tumours correlates with a kataegic pattern
of localised hypermutation. We assessed the cellular phenotypes associated with high-level …

Cancer is one of the most severe medical conditions in the world, causing millions of deaths
each year. Chemotherapy and radiotherapy are critical for treatment approaches, but both …

The DNA damage response (DDR) is recognized as having an important role in cancer
growth and treatment. ATR (ataxia telangiectasia mutated and Rad3-related) kinase, a major …

The combination of compounds with complementary bioactivities into hybrid molecules is an
emerging concept in drug discovery. In this study, we aimed to synthesize new hybrid …

Cancer cells generally possess higher levels of reactive oxygen species than normal cells,
and this can serve as a possible therapeutic target. In this proof-of-concept study, an …

Hybrid compounds combine fragments with complementary targets to achieve a common
pharmacological goal. This approach represents an increasingly popular strategy for drug …

Recent advances in mammography screening, chemotherapy, and adjuvant treatment
modalities have improved the survival rate of women with breast cancer. Nevertheless, the …

DNA damage responses contribute to cisplatin resistance; however, therapeutic strategies to
overcome cisplatin resistance have not yet been established. Here, we demonstrate that …