Macrophages are distributed in tissues throughout the body and contribute to both
homeostasis and disease. Recently, it has become evident that most adult tissue …

Neonates have little immunological memory and a developing immune system, which
increases their vulnerability to infectious agents. Recent advances in the understanding of …

Given the" inborn" nature of the innate immune system, it is surprising to find that innate
immune function does in fact change with age. Similar patterns of distinct Toll-like-receptor …

In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy,
in particular, is a time of increased disease susceptibility and severity. Early-life viral …

Newborn infants are highly susceptible to infection. This defect in host defence has
generally been ascribed to the immaturity of neonatal immune cells; however, the degree of …

The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

The fetus and newborn face a complex set of immunological demands, including protection
against infection, avoidance of harmful inflammatory immune responses that can lead to pre …

This work describes the nature and strength of the immune response induced by various Toll-
like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various …

Childhood adversity has been repeatedly and robustly linked to physical and mental illness
across the lifespan. Yet, the biological pathways through which this occurs remain unclear …

Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics
Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics Log …