Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant,
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic …
Role of glioblastoma stem cells in cancer therapeutic resistance: A perspective on antineoplastic agents from natural sources and chemical derivatives
ALV Alves, INF Gomes, AC Carloni, MN Rosa… - Stem Cell Research & …, 2021 - Springer
Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …
Overcoming therapeutic resistance in glioblastoma: the way forward
S Osuka, EG Van Meir - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …
The adaptive transition of glioblastoma stem cells and its implications on treatments
Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …
Radioresistance in Glioblastoma and the Development of Radiosensitizers
Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …
identified but have not yet resulted in development of effective radiosensitizer that can …
Hypoxic radioresistance: can ROS be the key to overcome it?
H Wang, H Jiang, M Van De Gucht, M De Ridder - Cancers, 2019 - mdpi.com
Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via
generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological …
generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological …
Breaking through the glioblastoma micro-environment via extracellular vesicles
T Simon, E Jackson, G Giamas - Oncogene, 2020 - nature.com
Glioblastoma (GBM) is the most common and most aggressive brain tumour. Prognosis
remains poor, despite the combined treatment of radio-and chemotherapy following surgical …
remains poor, despite the combined treatment of radio-and chemotherapy following surgical …
The role of hypoxia in glioblastoma radiotherapy resistance
AL Chédeville, PA Madureira - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GB) is the deadliest type of primary brain tumor. Following
diagnosis the patient´ s median survival is only 16 months. There are currently around 450 …
diagnosis the patient´ s median survival is only 16 months. There are currently around 450 …
Glioblastoma microenvironment and cellular interactions
Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …
Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment
Background Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after
therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is …
therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is …