The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

The promise of human embryonic stem cell (hESC) lines for treating injuries and
degenerative diseases, for understanding early human development, for disease modelling …

Current protocols for the scalable suspension culture of human pluripotent stem cells
(hPSCs) are limited by multiple biological and technical challenges that need to be …

Various somatic tissue‐derived mesenchymal stromal cells (MSCs) have been considered
as an attractive therapeutic tool for treatment of liver diseases in which the secretion of …

Recent advances in the generation of cardiomyocytes (CMs) from human pluripotent stem
cells (hPSCs), in conjunction with the promising outcomes from preclinical and clinical …

Our understanding of pluripotency remains limited: iPSC generation has only been
established for a few model species, pluripotent stem cell lines exhibit inconsistent …

Recent advances in human embryonic and induced pluripotent stem cell-based therapies in
animal models of hepatic failure have led to an increased appreciation of the need to …

Human cardiomyocytes (CM) differentiated from pluripotent stem cells (PSCs) are relatively
immature when generated in two-dimensional (2D) in vitro cultures, which limits their …

Background Retinal and/or optic nerve injury is one of the leading causes of blindness due
to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress …

Retinal organoids (ROs) derived from human-induced pluripotent stem cells recapitulate the
three-dimensional structure of retina, mimic human retinal development, and provide cell …