Current and future perspectives of liquid biopsies in genomics-driven oncology

E Heitzer, IS Haque, CES Roberts… - Nature Reviews …, 2019 - nature.com
Precision oncology seeks to leverage molecular information about cancer to improve patient
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …

Targeted therapies for renal cell carcinoma

EM Posadas, S Limvorasak, RA Figlin - Nature Reviews Nephrology, 2017 - nature.com
The management of patients with metastatic renal cell carcinoma (RCC) has changed
dramatically over the past few years. Nephrectomy remains an important intervention for …

The landscape of actionable genomic alterations in cell-free circulating tumor DNA from 21,807 advanced cancer patients

OA Zill, KC Banks, SR Fairclough, SA Mortimer… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Cell-free DNA (cfDNA) sequencing provides a noninvasive method for
obtaining actionable genomic information to guide personalized cancer treatment, but the …

Genomic landscape of cell-free DNA in patients with colorectal cancer

JH Strickler, JM Loree, LG Ahronian, AR Parikh… - Cancer discovery, 2018 - AACR
Abstract “Liquid biopsy” approaches analyzing cell-free DNA (cfDNA) from the blood of
patients with cancer are increasingly utilized in clinical practice. However, it is not yet known …

Generic protocols for the analytical validation of next-generation sequencing-based ctDNA assays: a joint consensus recommendation of the BloodPAC's Analytical …

JH Godsey, A Silvestro, JC Barrett, K Bramlett… - Clinical …, 2020 - academic.oup.com
Liquid biopsy, particularly the analysis of circulating tumor DNA (ctDNA), has demonstrated
considerable promise for numerous clinical intended uses. Successful validation and …

[HTML][HTML] Liquid biopsy in clinical management of breast, lung, and colorectal cancer

IB Hench, J Hench, M Tolnay - Frontiers in medicine, 2018 - frontiersin.org
Examination of tumor molecular characteristics by liquid biopsy is likely to greatly influence
personalized cancer patient management. Analysis of circulating tumor DNA (ctDNA) …

The potential of circulating cell-free RNA as a cancer biomarker: challenges and opportunities

IA Zaporozhchenko, AA Ponomaryova… - Expert review of …, 2018 - Taylor & Francis
Introduction: Cancer statistics show that recent improvements in cancer management are
only mildly effective in the absence of reliable biomarkers for the detection, diagnosis and …

[HTML][HTML] Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients

S Guo, X Shi, J Shen, S Gao, H Wang, S Shen… - British journal of …, 2020 - nature.com
Abstract Background About 25–37% of resectable pancreatic ductal adenocarcinoma
(PDAC) had a great chance of early recurrence after radical resection, which is mainly due …

Liquid biopsy for early diagnosis of non-small cell lung carcinoma: recent research and detection technologies

L Chang, J Li, R Zhang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Liquid biopsy, an innovative method for early diagnosis of cancer, has changed the
traditional method of diagnosing lung cancer and is considered a feasible auxiliary …

[HTML][HTML] Standard Operating Procedures (SOPs) for non-invasive multiple biomarkers detection in an academic setting: A critical review of the literature for the …

M Dameri, G Cirmena, F Ravera, L Ferrando… - Critical Reviews in …, 2023 - Elsevier
Liquid biopsy has the potential to drastically change clinical practice, paving the way to a
novel non-invasive approach for cancer diagnosis and treatment. One of the limitations for …