Synthetic lethal strategies for the development of cancer therapeutics
Synthetic lethality is a genetic phenomenon whereby the simultaneous presence of two
different genetic alterations impairs cellular viability. Importantly, targeting synthetic lethal …
different genetic alterations impairs cellular viability. Importantly, targeting synthetic lethal …
[HTML][HTML] The regulatory role of mitotic catastrophe in hepatocellular carcinoma drug resistance mechanisms and its therapeutic potential
J Li, X Cheng, D Huang, R Cui - Biomedicine & Pharmacotherapy, 2024 - Elsevier
This review focuses on the role and underlying mechanisms of mitotic catastrophe (MC) in
the regulation of drug resistance in hepatocellular carcinoma (HCC). HCC is one of the …
the regulation of drug resistance in hepatocellular carcinoma (HCC). HCC is one of the …
[HTML][HTML] A TRilogy of ATR's Non-Canonical Roles Throughout the Cell Cycle and Its Relation to Cancer
Abstract Ataxia Telangiectasia and Rad3-related protein (ATR) is an apical kinase of the
DNA Damage Response (DDR) pathway responsible for detecting and resolving damaged …
DNA Damage Response (DDR) pathway responsible for detecting and resolving damaged …
Pharmacogenomic discovery of genetically targeted cancer therapies optimized against clinical outcomes
P Truesdell, J Chang, D Coto Villa, M Dai… - NPJ Precision …, 2024 - nature.com
Despite the clinical success of dozens of genetically targeted cancer therapies, the vast
majority of patients with tumors caused by loss-of-function (LoF) mutations do not have …
majority of patients with tumors caused by loss-of-function (LoF) mutations do not have …
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
HA Segeren, KA Wierenga, FM Riemers, EA van Liere… - bioRxiv, 2024 - biorxiv.org
Oncogene-induced replication stress (RS) is a vulnerability of cancer cells that forces
reliance on the intra-S-phase checkpoint to ensure faithful genome duplication. Inhibitors of …
reliance on the intra-S-phase checkpoint to ensure faithful genome duplication. Inhibitors of …
Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells
Gemcitabine is a potent inhibitor of DNA replication and is a mainstay therapeutic for diverse
cancers, particularly pancreatic ductal adenocarcinoma (PDAC). However, most tumors …
cancers, particularly pancreatic ductal adenocarcinoma (PDAC). However, most tumors …