Postoperative systemic inflammatory dysregulation and corticosteroids: a narrative review
In some patients, the inflammatory‐immune response to surgical injury progresses to a
harmful, dysregulated state. We posit that postoperative systemic inflammatory dysregulation …
harmful, dysregulated state. We posit that postoperative systemic inflammatory dysregulation …
[HTML][HTML] Processed electroencephalography-guided general anaesthesia to reduce postoperative delirium: a systematic review and meta-analysis
Background Postoperative delirium (POD) is the most common serious postoperative
complication in older adults. It has uncertain aetiology, limited preventative strategies, and …
complication in older adults. It has uncertain aetiology, limited preventative strategies, and …
[HTML][HTML] Five commercial 'depth of anaesthesia'monitors provide discordant clinical recommendations in response to identical emergence-like EEG signals
Background 'Depth of anaesthesia'monitors claim to measure hypnotic depth during general
anaesthesia from the EEG, and clinicians could reasonably expect agreement between …
anaesthesia from the EEG, and clinicians could reasonably expect agreement between …
[HTML][HTML] A real-time neurophysiologic stress test for the aging brain: novel perioperative and ICU applications of EEG in older surgical patients
As of 2022, individuals age 65 and older represent approximately 10% of the global
population [1], and older adults make up more than one third of anesthesia and surgical …
population [1], and older adults make up more than one third of anesthesia and surgical …
[HTML][HTML] The drug titration paradox: more drug does not correlate with more effect in individual clinical data
TW Schnider, CF Minto, M Luginbühl… - British journal of …, 2022 - Elsevier
Background A fundamental concept in pharmacology is that increasing dose increases drug
effect. This is the basis of anaesthetic titration: the dose is increased when increased drug …
effect. This is the basis of anaesthetic titration: the dose is increased when increased drug …
Sevoflurane dose and postoperative delirium: a prospective cohort analysis
Background Recent trials are conflicting as to whether titration of anaesthetic dose using
electroencephalography monitoring reduces postoperative delirium. Titration to anaesthetic …
electroencephalography monitoring reduces postoperative delirium. Titration to anaesthetic …
Alternative per-protocol estimates: secondary analyses of data from the Balanced randomised controlled trial
J Young, T Short, LA Steiner, S Dell-Kuster - medRxiv, 2024 - medrxiv.org
Background The Balanced trial was designed to answer the question of whether anaesthetic
depth affects postoperative mortality when a vulnerable patient undergoes major surgery …
depth affects postoperative mortality when a vulnerable patient undergoes major surgery …
[HTML][HTML] The drug titration paradox: something obvious finally understood
TD Egan - British Journal of Anaesthesia, 2022 - Elsevier
The drug titration paradox is an emerging concept in clinical pharmacology. The paradox
refers to the observation that when drug is titrated to a specified level of effect in a population …
refers to the observation that when drug is titrated to a specified level of effect in a population …
Closed-loop control of anesthetic state in nonhuman primates
Research in human volunteers and surgical patients has shown that unconsciousness
under general anesthesia can be reliably tracked using real-time electroencephalogram …
under general anesthesia can be reliably tracked using real-time electroencephalogram …
Beware the drug titration paradox. Comment on Br J Anaesth 2021; 127: 704–12
TW Schnider, CF Minto - British Journal of Anaesthesia, 2022 - bjanaesthesia.org
EditordWe read with interest the article by Evered and colleagues 1 concerning depth of
anaesthesia and the risk of developing new onset postoperative delirium (POD). They …
anaesthesia and the risk of developing new onset postoperative delirium (POD). They …