T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …

SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to
neutralization following immunization with ancestral spike-matched vaccines. It is unclear …

T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune
responses to mediate inflammation and regulate other types of immune cells. Work in the …

Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …

Although many kinds of therapies are applied in the clinic, drug-resistance is a major and
unavoidable problem. Another disturbing statistic is the limited number of drug targets, which …

The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …

Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …