While many viral infections are limited and eventually resolved by the host immune
response or by death of the host, other viruses establish long-term relationships with the …

Background Human cytomegalovirus (HCMV) resides latently in cells of the myeloid
compartment, including CD34+ hematopoietic progenitor cells and circulating monocytes …

Infections with human cytomegalovirus (HCMV) are often asymptomatic in healthy adults but
can be severe in people with a compromised immune system. While several studies have …

Suppression of human cytomegalovirus (HCMV) major immediate early gene (IE)
expression from the viral major immediate early promoter (MIEP) is known to be crucial for …

Leishmania donovani, an intracellular protozoan parasite, is the causative agent of visceral
leishmaniasis, the most severe form of leishmaniasis in humans. It is becoming increasingly …

Herpesviruses are ubiquitous pathogens that establish lifelong, latent infections in their host.
Spontaneous reactivation of herpesviruses is often asymptomatic or clinically manageable …

Human cytomegalovirus (HCMV) presents a major health burden in the
immunocompromised and in stem cell transplant medicine. A lack of understanding about …

Human cytomegalovirus (HCMV) infection is not cleared by the initial immune response but
persists for the lifetime of the host, in part due to its ability to establish a latent infection in …

Human cytomegalovirus (HCMV) establishes either a latent (non-productive) or lytic
(productive) infection depending upon cell type, cytokine milieu and the differentiation status …

Human cytomegalovirus (HCMV) can undergo either a latent or a lytic infection in cells of the
myeloid lineage. Whilst the molecular mechanisms which determine the outcome of infection …