Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

Esophageal squamous cell carcinoma (ESCC) is prevalent worldwide and particularly
common in certain regions of Asia. Here we report the whole-exome or targeted deep …

Dissecting the pathogenesis of classical Hodgkin lymphoma (cHL), a common cancer in
young adults, remains challenging because of the rarity of tumor cells in involved tissues …

Shuttling of specific proteins out of the nucleus is essential for the regulation of the cell cycle
and proliferation of both normal and malignant tissues. Dysregulation of this fundamental …

Purpose This trial evaluated the safety, pharmacokinetics, pharmacodynamics, and efficacy
of selinexor (KPT-330), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1) …

Purpose: Next-generation sequencing (NGS) has detailed the genomic characterization of
diffuse large B-cell lymphoma (DLBCL) by identifying recurrent somatic mutations. We set …

The key nuclear export protein CRM1/XPO1 may represent a promising novel therapeutic
target in human multiple myeloma (MM). Here we showed that chromosome region …

The common participation of oncogenic KRAS proteins in many of the most lethal human
cancers, together with the ease of detecting somatic KRAS mutant alleles in patient samples …