Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

The maize pathogen Ustilago maydis has to undergo various morphological transitions for
the completion of its sexual life cycle. For example, haploid cells respond to pheromone by …

Ubiquitin (Ub) chain formation by homologous to E6AP C-terminus (HECT)-family E3 ligases
regulates vast biology, yet the structural mechanisms remain unknown. We used chemistry …

Amyotrophic lateral sclerosis (ALS) is a fatal, late-onset neurodegenerative disease
primarily affecting motor neurons. A unifying feature of many proteins associated with ALS …

Long-distance transport of mRNAs is important in determining polarity in eukaryotes.
Molecular motors shuttle large ribonucleoprotein complexes (mRNPs) containing RNA …

The conserved RNA binding protein La recognizes UUU-3′ OH on its small nuclear RNA
ligands and stabilizes them against 3′-end-mediated decay. We report that newly …

An emerging theme in cellular logistics is the close connection between mRNA and
membrane trafficking. A prominent example is the microtubule-dependent transport of …

RNA-binding proteins are of vital importance for mRNA functioning. Among these, poly (A)-
binding proteins (PABPs) are of special interest due to their participation in virtually all …

miRNA‐mediated gene silencing requires the GW182 proteins, which are characterized by
an N‐terminal domain that interacts with Argonaute proteins (AGOs), and a C‐terminal …

Oomycete pathogens deliver many effectors to enhance virulence or suppress plant
immunity. Plant immune networks are interconnected, in which a few effectors can trigger a …