The compilation of multiple metazoan genome sequences and the deluge of large-scale
expression data have combined to motivate the maturation of bioinformatics methods for the …

Identifying genomic locations of transcription-factor binding sites, particularly in higher
eukaryotic genomes, has been an enormous challenge. Various experimental and …

ConSite is a user-friendly, web-based tool for finding cis-regulatory elements in genomic
sequences. Predictions are based on the integration of binding site prediction generated …

Mutations in cystic kidney disease genes represent a major genetic cause of end‐stage
renal disease. However, the molecular cascades controlling the expression of these genes …

Mutations in the gene for the transcription factor hepatocyte nuclear factor (HNF) 1alpha
cause maturity-onset diabetes of the young (MODY) 3, a form of diabetes that results from …

Computational analysis of polymerase II (Pol II) promoters may contribute to improved gene
identification and to prediction of the expression context of genes. Before assessing the state …

A major mode of gene regulation occurs via the binding of specific proteins to specific DNA
sequences. The availability of complete bacterial genome sequences offers an …

Elucidating the human transcriptional regulatory network 1 is a challenge of the post-
genomic era. Technical progress so far is impressive, including detailed understanding of …

For many newly sequenced genes, sequence analysis of the putative protein yields no clue
on function. It would be beneficial to be able to identify in the genome the regulatory regions …

Background The binding of transcription factors to specific locations in the genome is
integral to the orchestration of transcriptional regulation in cells. To characterize transcription …